Adaptive Clinical Trials
نویسندگان
چکیده
منابع مشابه
Adaptive Design for Clinical Trials
Adaptive design is a trial design that allows modifications to some aspects of the trial after its initiation without undermining the validity and integrity of the trial. Adaptive design makes it possible to discover and rectify inappropriate assumptions in trial designs, lower development costs and reduce the time to market. It has become very attractive to the pharmaceutical industries. In th...
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In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
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Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...
متن کاملBayesian Adaptive Designs for Clinical Trials
A Bayesian adaptive design is proposed for a comparative two-armed clinical trial using decision theoretical approaches. A loss function is specified to consider the cost for each patient, and the costs of making incorrect decisions at the end of a trial. At each interim analysis, the decision to terminate or to continue the trial is based on the expected loss function while concurrently incorp...
متن کاملPractical Bayesian adaptive randomisation in clinical trials.
While randomisation is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favours one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favoured treatment, rather than e...
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ژورنال
عنوان ژورنال: Therapeutic Innovation & Regulatory Science
سال: 2014
ISSN: 2168-4790,2168-4804
DOI: 10.1177/2168479013513889